Touted as "one of America's most haunted homes", the plantation is supposedly the home of at least 12 ghosts.
It is often reported that 10 murders occurred in the house, but historical records only indicate the murder of William Winter.
William Drew Winter is also a very popular character in the plantation.
He was an attorney who lived in the plantation from 1865 until 1871. He
was shot by a stranger. After being shot, he staggered inside the house
and died trying to climb the stairs. He died on the 17th step of the
stairs. Until today, visitors, as well as employees in the hotel, still
hear his dying footsteps. 

In 2002, Unsolved Mysteries filmed a segment about the alleged hauntings at the plantation. According to host Robert Stack,
the production crew experienced technical difficulties during the
production of the segment. The Myrtles was also featured on a 2005
episode of Ghost Hunters.  The TV series Ghost Adventures also filmed an episode there.